MOTS-c (10mg) – Mitochondrial-Derived Peptide (MDP)

Overview

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring 16-amino acid peptide encoded by the mitochondrial genome. As a member of the Mitochondrial-Derived Peptide (MDP) family, MOTS-c is a primary subject of study in retrograde signaling—the process by which mitochondria communicate with the nuclear genome to regulate cellular homeostasis.

Biochemical Profile

• Amino Acid Sequence: $MRWQVMIVGMKDGVVF$

• Molecular Formula: $C_{101}H_{152}N_{28}O_{22}S_{2}$

• Molecular Weight: $2174.6$ g/mol

• Purity: ≥ 98% (HPLC Analysis)

• Source: Synthetic (identical to mitochondrial-encoded sequence)

Primary Research Objectives

In vitro and in vivo research models utilize MOTS-c to investigate the following biochemical pathways:

• AMPK Signaling: Research into the activation of the AMP-activated protein kinase (AMPK) pathway.

• Mitochondrial Proteostasis: Studies focusing on how MDPs influence cellular stress responses.

• Glucose Transporter Kinetics: Investigation of the GLUT4 translocation process in cellular models.

• Metabolic Flux Analysis: Observation of lipid and glucose oxidation rates in laboratory environments.

• Epigenetic Regulation: Studying the interaction between mitochondrial peptides and nuclear gene expression.

Handling & Storage

• Stability: Lyophilized powder is stable at room temperature for 90 days, but -20°C storage is recommended for long-term integrity.

• Post-Reconstitution: Once reconstituted with an appropriate laboratory buffer (e.g., Bacteriostatic Water), the solution must be stored at 2°C to 8°C.