MOTS-c (10mg) – Mitochondrial-Derived Peptide (MDP)

Overview

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring 16-amino acid peptide encoded by the mitochondrial genome. As a member of the Mitochondrial-Derived Peptide (MDP) family, MOTS-c is a primary subject of study in retrograde signaling—the process by which mitochondria communicate with the nuclear genome to regulate cellular homeostasis.

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Biochemical Profile

• Amino Acid Sequence: MRWQVMIVGMKDGVVF

• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂

• Molecular Weight: 2174.6 g/mol

• Purity: See Certificate of Analysis

• Source: Synthetic (identical to mitochondrial-encoded sequence)

Primary Research Objectives

In vitro and in vivo research models utilize MOTS-c to investigate the following biochemical pathways:

• AMPK Signaling: Research into the activation of the AMP-activated protein kinase (AMPK) pathway.

• Mitochondrial Proteostasis: Studies focusing on how MDPs influence cellular stress responses.

• Glucose Transporter Kinetics: Investigation of the GLUT4 translocation process in cellular models.

• Metabolic Flux Analysis: Observation of lipid and glucose oxidation rates in laboratory environments.

• Epigenetic Regulation: Studying the interaction between mitochondrial peptides and nuclear gene expression.

Handling & Storage

• Stability: Lyophilized powder is stable at room temperature for 90 days, but -20°C storage is recommended for long-term integrity.

• Post-Reconstitution: Once reconstituted with an appropriate laboratory buffer (e.g., Bacteriostatic Water), the solution must be stored at 2°C to 8°C.

For research use only.